Figure 2.

Schematic of HBV DNA and RNA kinetics during acute or chronic infection. Relative DNA (gray) and pgRNA (blue) concentrations in the serum during HBV infection. In acute infection (A), increasing viral replication results in elevated HBV DNA until spontaneous resolution and loss of DNA detection. pgRNA follows the same kinetics but remains consistently lower than the DNA viral load. During chronic infection, HBV DNA and pgRNA levels can remain detectable over time (B). Commencing treatment with NAs (NA start) can rapidly reduce DNA (C, D) while pgRNA remains detectable. Decreasing cccDNA activity (asterisk) would result in reduced pgRNA levels (D).