Table 5. The top 10 significant results from an epigenome-wide association study (EWAS) of age carried out using EDTA samples.
For the first 10 loci, the CpG name, the symbol and name of the gene that the CpG is located in (or NA if the CpG is not located in a gene), genomic coordinate of the CpG (GRCh37), t-statistic and p-value are shown. Results are ranked by p-value.
| CpG Name | Gene Symbol | Gene Name | Chr. | Position | t | p-value |
|---|---|---|---|---|---|---|
| cg16867657 | ELOVL2 | ELOVL fatty acid elongase 2 | 6 | 11044877 | 11.61 | 4.88 × 10 -14 |
| cg22454769 | FHL2 | four and a half LIM domains 2 | 2 | 106015767 | 7.94 | 1.41 × 10 -9 |
| cg10501210 | NA | NA | 1 | 207997020 | -7.91 | 1.53 × 10 -9 |
| cg07547549 | SLC12A5 | solute carrier family 12 member 5 | 20 | 44658225 | 7.48 | 5.71 × 10 -9 |
| cg16419235 | PENK | proenkephalin | 8 | 57360613 | 7.34 | 8.83 × 10 -9 |
| cg06639320 | FHL2 | four and a half LIM domains 2 | 2 | 106015739 | 7.29 | 1.01 × 10 -8 |
| cg21572722 | ELOVL2 | ELOVL fatty acid elongase 2 | 6 | 11044894 | 6.68 | 6.78 × 10 -8 |
| cg23606718 | AMER3 | APC membrane recruitment protein 3 | 2 | 131513927 | 6.60 | 8.74 × 10 -8 |
| cg17737621 | NA | NA | 20 | 21372480 | 6.60 | 8.80 × 10 -8 |
| cg23500537 | NA | NA | 5 | 140419819 | 6.57 | 9.58 × 10 -8 |