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Effects of aqueous extract of Withania somnifera root, methotrexate therapy on joint tissue. No sign of inflammation and cartilage destruction in control rats (A), large influx of inflammatory cells, pannus formation, cartilage destruction in CIA rats (B), shows significant less inflammation in MTX (C) and WSAq300 (D) treated rats (E) Scoring of histopathological changes. ***p<0.0001 vs. control rats, #p<0.0001 vs. CIA rats.
