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. 2019 Apr 1;33(7-8):382–387. doi: 10.1101/gad.323105.118

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© 2019 Zhang et al.; Published by Cold Spring Harbor Laboratory Press

This article is distributed exclusively by Cold Spring Harbor Laboratory Press for the first six months after the full-issue publication date (see http://genesdev.cshlp.org/site/misc/terms.xhtml). After six months, it is available under a Creative Commons License (Attribution-NonCommercial 4.0 International), as described at http://creativecommons.org/licenses/by-nc/4.0/.

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Figure 1. — H3K27me3 is enriched at developmental gene promoters in the human morula. (A) A schematic summary of the data sets generated in this study. H3K27me3 CUT&RUN was performed using pooled morulae collected from couple 1 (C1; n = 7) and couple 2 (C2; n = 8). Three replicates for single morula RNA-seq were performed for each couple. (B) Heat map showing gene expression levels and H3K27me3 enrichment at the corresponding gene bodies in human morulae. RPKM values are Z-score normalized and log2-transform normalized for CUT&RUN and RNA-seq, respectively. (C) A genome browser view showing H3K27me3 enrichment at HOXA and HOXD clusters, PAX6, and SOX3 in both morula and human embryonic stem cells (hESCs). (D) Heat map showing enrichment of H3K27me3 at promoters (transcription start site ± 2.5 kb) in morulae (two replicates) and hESCs. RPKM was subject to Z-score normalization.