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. 2019 Apr 1;33(7-8):382–387. doi: 10.1101/gad.323105.118

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© 2019 Zhang et al.; Published by Cold Spring Harbor Laboratory Press

This article is distributed exclusively by Cold Spring Harbor Laboratory Press for the first six months after the full-issue publication date (see http://genesdev.cshlp.org/site/misc/terms.xhtml). After six months, it is available under a Creative Commons License (Attribution-NonCommercial 4.0 International), as described at http://creativecommons.org/licenses/by-nc/4.0/.

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Figure 3. — A subset of paternally expressed genes (PEGs) harbor germline differentially methylated regions (DMRs). (A) Heat map showing PEGs identified in this study. Each column represents one morula; a total of three morulae were analyzed for each couple. PEGs with oocyte hyper-DMR within 10 kb of the genes were considered as DMR-related (top panel). The remaining was considered as DMR unrelated (bottom panel). (B) Genome browser view showing examples of PEGs containing oocyte hyper-DMRs at promoter regions. DNA methylation in oocyte, sperm, and morula is shown.