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. 2019 Apr 1;33(7-8):452–465. doi: 10.1101/gad.321489.118

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© 2019 Lam et al.; Published by Cold Spring Harbor Laboratory Press

This article, published in Genes & Development, is available under a Creative Commons License (Attribution 4.0 International), as described at http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Figure 6. — A schematic model. The NSL complex is required for nucleosome positioning at dispersed promoters of housekeeping genes. Genetic and biochemical analysis revealed that the NSL complex recruits NURF chromatin remodeling complex at target promoters. The NSL complex targets AT-rich sequences in TATA-less promoters. Loss of NSL complex not only leads to transcription down-regulation of targets but also affects the choice of TSSs of highly expressed genes with multiple TSSs. Loss of NSL complex also increases transcription noise at target genes. Thus, NSL complex plays a crucial role in transcription fidelity in the Drosophila genome.