Skip to main content
. Author manuscript; available in PMC: 2019 Apr 3.
Published in final edited form as: Bioconjug Chem. 2019 Mar 4;30(3):944–951. doi: 10.1021/acs.bioconjchem.9b00047

Figure 5.

Figure 5.

Pro-inflammatory cytokine production by peritoneal macrophages. The effects of free inhibitor or LSNA treatment on dual TLR4- and TLR9-stimulated peritoneal macrophages was measured by the number of IL-6 (A-C) and TNFα (D-F) producing cells during simultaneous treatment, pretreatment of inhibitors or LSNAs, and post-treatment of inhibitors or LSNAs. Results indicated that only a combination of TAK-242 and INH-18, whether free in solution or incorporated into an LSNA, resulted in decreased IL-6 and TNFα production. (*P < 0.05).