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. Author manuscript; available in PMC: 2020 Apr 1.
Published in final edited form as: Hum Immunol. 2019 Feb 6;80(4):228–236. doi: 10.1016/j.humimm.2019.01.009

Table 3B:

Unresolved null allele ambiguity

Null allele ambiguity Difference Description
HLA-A*68:02:01:01/HLA-A*68:18N Exon 2 20 bp insertion between codons 47 and 48
HLA-A*31:14N/HLA-A*31:01:02:01 Exon 4 Insertion of a “C” between codons 185 and 186
HLA-B*15:01:01:01/HLA-B*15:01:14/HLA-B*15:26N Exon 3 Codon 99 TAC (Tyr) -> TAA (Stop)
HLA-B*44:02:01:03/HLA-B*44:19N Exon 1 Deletion of a “G” in codon −23
HLA-DRB4*01:03:01:01/HLA-DRB4*01:03:01:02N/HLA-DRB4*01:03:01:03 Intron 1 Single nucleotide change G->A at the 3’ end of intron 1
HLA-DRB5*01:02/HLA-DRB5*01:10N Exon 2 2bp deletion in codon 80

Observed null ambiguities are listed in column “Null allele ambiguity”. The null ambiguities likely result from shallow DNA sequence coverage (below the software threshold) for the specific exon or intron region shown in column “Difference”. The “Description” column describes the sequence change that results in the null allele.