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. Author manuscript; available in PMC: 2020 Apr 1.
Published in final edited form as: Genet Epidemiol. 2019 Feb 11;43(3):276–291. doi: 10.1002/gepi.22194

Table 6:

Simulation for SNP data (n, p) = (300, 505) under AR structures. 50 genes have nonzero regression coefficients. 5 clinical covariates are not subject to selection. The SNPs have AR structure with ρ = 0.5 (upper panel) and ρ = 0.8 (lower panel). mean(sd) of true positives (TP) and false positives (FP) based on 100 replicates.

LAD_Network LAD_MCP LAD_LASSO Network MCP LASSO
AR ρ = 0.5
Error1 TP 39.97(9.05) 39.77(3.54) 34.50(6.24) 33.50(6.60) 29.83(6.88) 46.03(2.30)
FP 8.83(5.80) 9.33(7.71) 106.03(37.94) 9.13(6.26) 8.77(5.17) 84.53(11.25)
Error2 TP 23.23(10.57) 22.43(10.93) 27.43(8.64) 5.17(9.41) 6.93(14.32) 6.10(8.79)
FP 23.93(40.56) 57.97(95.48) 110.17(66.55) 32.03(86.43) 45.67(126.72) 23.67(39.83)
Error3 TP 37.03(10.07) 36.17(4.53) 34.30(6.39) 16.17(11.50) 15.07(10.51) 28.30(16.74)
FP 9.00(6.44) 15.93(26.06) 107.77(43.29) 8.50(5.76) 8.30(5.45) 58.40(34.86)
Error4 TP 38.13(7.35) 34.17(6.01) 34.90(7.04) 10.63(10.55) 9.83(9.89) 19.90(17.49)
FP 10.17(6.86) 27.17(41.85) 109.70(45.23) 6.73(6.10) 6.07(6.49) 40.63(41.16)
AR ρ = 0.8
Error1 TP 46.87(5.11) 45.30(2.87) 42.87(6.06) 48.70(1.42) 26.07(3.49) 48.73(1.01)
FP 3.80(2.96) 3.47(2.66) 104.20(30.42) 10.00(7.89) 6.67(3.39) 60.00(12.99)
Error2 TP 38.80(10.71) 26.17(6.93) 35.93(4.16) 5.97(10.07) 6.10(12.41) 5.70(7.53)
FP 12.20(8.02) 44.20(83.64) 105.40(32.2) 35.30(89.14) 43.57(111.1) 25.77(42.43)
Error3 TP 46.70(6.02) 39.90(5.94) 43.17(3.65) 33.23(16.9) 18.10(9.78) 33.97(15.77)
FP 6.77(5.88) 6.10(10.6) 105.63(28.03) 18.97(16.06) 20.83(65.59) 60.93(29.47)
Error4 TP 42.87(10.92) 36.03(6.83) 42.17(4.47) 25.93(16.99) 13.43(8.39) 29.33(15.39)
FP 5.67(4.56) 10.30(21.71) 120.90(48.61) 19.77(13.39) 7.57(6.82) 50.30(31.1)