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. Author manuscript; available in PMC: 2020 Apr 1.
Published in final edited form as: Genet Epidemiol. 2019 Feb 11;43(3):276–291. doi: 10.1002/gepi.22194

Table 7:

Simulation for SNP data (n, p) = (300, 505) under banded structures. 50 genes have nonzero regression coefficients. 5 clinical covariates are not subject to selection. The SNPs have Banded.1 (upper panel) or Banded.2 structure (lower panel) with ρ = 0.5. mean(sd) of true positives (TP) and false positives (FP) based on 100 replicates.

LAD_Network LAD_MCP LAD_LASSO Network MCP LASSO
Banded.1 ρ = 0.5
Error1 TP 39.17(9.57) 36.87(8.19) 30.13(8.40) 31.80(3.95) 26.57(4.39) 43.97(3.18)
FP 9.10(5.92) 13.53(21.54) 91.63(43.74) 8.27(5.30) 8.53(6.22) 81.93(12.6)
Error2 TP 19.17(9.70) 18.30(13.42) 25.43(8.69) 2.83(7.39) 3.60(9.97) 3.17(5.17)
FP 14.93(13.16) 57.30(93.44) 97.63(51.97) 17.30(60.78) 24.20(89.50) 13.10(27.14)
Error3 TP 33.33(10.57) 32.47(4.61) 29.97(8.37) 14.60(13.06) 12.83(11.25) 24.40(17.98)
FP 8.00(4.61) 18.57(38.32) 101.23(52.47) 8.13(7.21) 6.63(6.19) 53.10(37.71)
Error4 TP 33.53(13.54) 29.43(8.05) 31.00(6.77) 11.43(8.63) 10.83(7.73) 24.40(12.76)
FP 16.37(12.94) 18.30(36.76) 108.90(39.14) 7.07(7.91) 6.53(5.78) 56.57(30.96)
Banded.2 ρ = 0.5
Error1 TP 41.23(8.78) 40.57(3.30) 34.23(7.57) 32.23(6.74) 27.77(5.10) 45.93(1.76)
FP 10.83(7.68) 9.17(7.45) 113.63(46.59) 9.63(6.7) 9.30(4.23) 84.00(12.91)
Error2 TP 21.10(7.69) 20.53(13.05) 27.27(8.2) 1.60(1.96) 1.63(2.11) 3.03(4.19)
FP 17.27(10.43) 76.43(122.77) 93.57(49.76) 5.10(10.5) 5.00(10.3) 11.40(15.40)
Error3 TP 35.60(9.11) 34.90(4.48) 34.20(5.11) 15.30(10.17) 14.37(9.68) 28.67(16.14)
FP 10.60(7.02) 15.63(38.21) 117.63(38.53) 9.80(7.23) 9.50(7.10) 66.77(37.00)
Error4 TP 38.50(8.44) 36.47(5.17) 33.20(7.07) 12.43(10.86) 11.80(10.26) 21.80(18.26)
FP 18.77(13.23) 41.57(69.17) 109.73(42.16) 11.13(26.16) 12.90(30.37) 45.90(38.12)