Table 5.
Mean score (±SD) of seven signs before and during the follow-up visits in 103 patients with Meibomian gland dysfunction, treated with either oral doxycycline or azithromycin, plus VA evaluations
| MG secretion | MG plugging | Bulbar conjuntival redness | Em redness | Schirmer I | TBUT | Staining | VA | P | |
|---|---|---|---|---|---|---|---|---|---|
| Pretreatment signs AZT | 1.8 (0.7) | 2 (0.7) | 1.6 (0.6) | 2 (0.6) | 1.2 (0.4) | 1.3 (0.5) | 1.7 (0.7) | 0.6 (0.1) | >0.005 |
| Pretreatment signs DOXY | 1.5 (0.7) | 1.6 (0.5) | 2 (0.8) | 1.5 (0.7) | 1 (0) | 1.7 (0.7) | 1.6 (0.5) | 0.6 (0.1) | |
| First control signs AZT | 1 (0.4) | 1.3 (0.5) | 0.9 (0.4) | 1.2 (0.6) | 1.1 (0.4) | 1.1 (0.4) | 0.9 (0.4) | 0.7 (0.1) | >0.005 |
| First control signs DOXY | 1.1 (0.6) | 1.1 (0.3) | 1 (0) | 1.4 (0.5) | 1 (0) | 1.1 (0.3) | 0.7 (0.5) | 0.8 (0.1) | |
| Second control signs AZT | 0.6 (0.7)* | 0.9 (0.5) | 0.5 (0.5)* | 1 (0.4) | 1 (0.4) | 0.9 (0.4) | 0.4 (0.5)* | 0.9 (0.1)* | >0.005 |
| Second control signs DOXY | 0.9 (0.7)* | 1.1 (0.7) | 0.8 (0.4)* | 1 (0) | 0.9 (0.3) | 1 (0) | 1.1 (0.3)* | 0.75 (0.1)* | <0.005* |
| Third control signs AZT | 0.7 (0.6)* | 0.9 (0.5) | 0.6 (0.5)* | 0.7 (0.5) | 1 (0.3) | 1 (0.2) | 0.6 (0.5) | 0.9 (0.1)* | >0.005 |
| Third control signs DOXY | 1 (0)* | 0.8 (0.6) | 1 (0)* | 0.8 (0.4) | 1 (0) | 1 (0) | 0.7 (0.5) | 0.7 (0.2)* | <0.005* |
| Third control signs AZT and DOXY | 1.2 (0.4) | 0.9 (0.3) | 0.7 (0.5)* | 0.8 (0.4) | 1.1 (0.3) | 1.2 (0.4) | 0.7 (0.5*) | 0.9 (0.2)* | >0.005 |
| Third control signs DOXY and AZT | 0.9 (0.6) | 1.1 (0.6) | 1.3 (0.5)* | 0.8 (0.4) | 1.2 (0.4) | 1.2 (0.4) | 1.2 (0.6)* | 0.7 (0.1)* | <0.005* |
| Fourth control signs AZT | 0.8 (0.5)* | 0.7 (0.5) | 0.6 (0.5)* | 0.6 (0.5) | 1.2 (0.4) | 1 (0)* | 0.7 (0.5) | 0.9 (0.1) | >0.005 |
| Fourth control signs AZT and DOXY | 1 (0.5)* | 0.7 (0.5) | 0.8 (0.4)* | 0.5 (0.5) | 1.3 (0.5) | 1.3 (0.5)* | 0.7 (0.5) | 0.9 (0.1) | <0.005* |
| Fourth control signs DOXY | 0.9 (0.3)* | 0.9 (0.3) | 1 (0) | 0.9 (0.3) | 1 (0)* | 1 (0) | 1.1 (0.3) | 0.85 (0.1) | >0.005 |
| Fourth control signs DOXY and AZT | 1.2 (0.4)* | 0.9 (0.4) | 1.1 (0.4) | 0.9 (0.4) | 1.2 (0.4)* | 1.1 (0.4) | 1.1 (0.3) | 0.8 (0.1) | <0.005* |
Statistical significance in signs during follow-ups are colored in grey. VA: Visual acuity; Mg: Meibomian gland; TBUT: Tear break-up time; SD: Standard deviation; AZT: Azythromicin; DOXY: Doxycycline; *Statistical significance