Table 1.
Lateralization of ACTH source on BIPSS with ACTH ratio and prolactin-adjusted ACTH ratio, MRI, and intraoperative localization of transsphenoid surgery
| Age (years)/sex | Drug used during BIPSS | Dose | Lateralization with different modalities | Histopathology | ||||
|---|---|---|---|---|---|---|---|---|
| Intersinus ACTH ratio ≥1.4 | Prolactin adjusted ACTH ratio | MRI | Size of tumor (mm) | TSS localization | ||||
| 26/M | Vasopressin | 5 unit | Right | Right | Right | 6 × 5 | Right | Adenoma |
| 25/F | Human CRH | 100 mm | Right | Right | Right | 9 × 8 | Left | Adenoma |
| 21/F | Human CRH | 100 mg | Right | Right | Right | 8 × 8 × 6 | Right | Adenoma |
| 28/F | Human CRH | 100 mg | Right | Left | Right | 9 × 7 × 4 | Right | Adenoma |
| 25/M | Human CRH | 100 mg | Right | Right | Right | 5 × 3 | Right | Adenoma |
| 16/F | Human CRH | 100 mg | Right | Right | Left | 4.8 × 4.0 | Left | Adenoma |
| 26/F | Human CRH | 100 mg | Right | Right | Normal | Normal | Right | Adenoma |
| 25/M | Human CRH | 100 mg | Right | Right | Left | 6.9 × 0.5 | Left | Adenoma |
ACTH: Adrenocorticotropic hormone; BIPSS: Bilateral inferior petrosal sinus sampling; MRI: Magnetic resonance imaging; CRH: Corticotropin releasing hormone