Fig. 1.

dOFM study design. All rats were treated with topical IMQ on one side of the back to induce local inflammation. In addition, 6 of the 12 rats received systemic oral DEX treatment. Samples were collected from each side with three dOFM probes. The magnified right part of the figure shows a schematic representation of the dOFM sampling used (10, 56), demonstrating the collection of diluted ISF directly from the skin; the image on the left shows a rat during sampling and a close-up of the IMQ-treated test site.