Fig. 9.

Rosi-mediated metabolic and structural remodeling of human adipocytes. Activation of PPARγ with Rosi drove transcriptional changes that reprogrammed lipid metabolism in mature white adipocytes from both visceral and subcutaneous adipose tissues. The high oxidative capacity in the brite adipocytes was accompanied by a structural remodeling of LDs and mitochondria. Clusters of SLDs were formed, decorated with PLIN5, and became closely associated with rearranged mitochondria. These small droplets were formed through reesterification of FAs released by lipolysis.