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. 2019 Jan 20;60(4):844–855. doi: 10.1194/jlr.M090969

Fig. 4.

Fig. 4.

Knockdown of CD36 increases lipophagy and β-oxidation and inhibition of autophagy reduces lipophagy and β-oxidation. A–C: Autophagosomal (LC3/BODIPY) and lysosomal (LysoTracker/BODIPY) colocalization with lipids under PA treatment. Thirty cells were used for the statistical analysis of the number of confocal puncta per cell. D, E: Oxygen consumption rate in HepG2 cells. F: Intracellular TG content in HepG2 cells with PA treatment. G: Western blotting analysis of CPT1a in WT and CD36−/− mice fed the HFD. H: CPT1a protein level in HepG2 cells with PA treatment. I: CPT1a mRNA level in WT and CD36−/− mice fed the HFD. Data are presented as means ± SDs; n = 3 for A–F and H, *P < 0.05 versus siNeg groups and #P < 0.05 versus siCD36 groups; n = 6 for G and I, *P < 0.05 and **P < 0.01 versus WT HFD groups.