Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Mitofusin‐2 (Mfn2) regulatory pathway. Peroxisome proliferator‐activated receptor gamma coactivator 1α (PGC‐1α) and PGC‐1β are positive regulators of Mfn2 activity. Mfn2 is induced by PGC‐1α in response to exercise, cold exposure or β3 adrenergic agonists, whereas under basal conditions PGC‐1β activates Mfn2. This involves activation of the Mfn2 promoter through an estrogen‐related receptor α (ERRα)‐binding element.
