Table 1.

Backward stepwise multivariable logistic regression of predictors recorded at age 3 years, for possibility of developing asthma at school‐age

	Adjusted ORs (P‐values)	RC	Bootstrapping [RC 95%CI]	Biasa	Simplified RC
Demographic and perinatal data
Gender	1.082 (0.820)	‐	‐	‐	‐
Paternal asthma ever	1.363 (0.474)	‐	‐	‐	‐
Maternal asthma ever	0.802 (0.557)	‐	‐	‐	‐
Paternal smoking at recruitment	1.037 (0.940)	‐	‐	‐	‐
Maternal smoking at recruitment	0.956 (0.968)	‐	‐	‐	‐
Paternal smoking age 3	0.829 (0.645)	‐	‐	‐	‐
Maternal smoking at age 3	1.403 (0.408)	‐	‐	‐	‐
Parental atopy (at least one parent)	0.993 (0.989)	‐	‐	‐	‐
Wheeze‐related symptoms at age 3
Wheeze require meds	1.309 (0. 496)	‐	‐	‐	‐
Wheeze without cold	1.739 (0.136)	‐	‐	‐	‐
Wheeze with cold air	1.062 (0.917)	‐	‐	‐	‐
Wheeze after exercise	2.679 (0.018)	0.985	[0.146‐1.899]	0.026	1
Wheeze causes SOB	2.343 (0.007)	0.851	[0.255‐1.525]	0.020	1
Wheeze attack of more than three times	1.269 (0.625)	‐	‐	‐	‐
Atopic status
Current eczema	2.627 (0.002)	0.966	[0.354‐1.634]	0.021	1
SPT sensitisation	3.342 (<0.001)	1.207	[0.549‐1.887]	0.012	1
Physician‐diagnosed hayfever/allergic rhinitis	0.918 (0.885)	‐	‐	‐	‐
Cough‐related symptoms at age 3
Cough mainly at night	0.897 (0.736)	‐	‐	‐	‐
Cough when excited	1.000 (1.000)	‐	‐	‐	‐
Congestion/phlegm apart from colds	3.091 (0.079)	‐	‐	‐	‐
Cough on exertion	2.972 (0.001)	1.089	[0.414‐1.895]	0.047	1
Cough with cold air	1.238 (0.603)	‐	‐	‐	‐

The MAAS APT to be applied at age 3 years to predict asthma at school‐age
	Responses:
✓Do the wheeze attacks cause shortness of breath? (1)	Y□ N□
✓Does the child wheeze after exercise? (1)	Y□ N□
✓Does the child cough after exertion? (1)	Y□ N□
✓Does the child have eczema currently? (1)	Y□ N□
✓Is the child skin prick test positive to common allergens? (1)	Y□ N□
Total score	__/5
0 ‐ low risk	□
1‐2 ‐ Medium/indeterminate risk	□
≥3 ‐ High Risk	□

RC, Regression coefficient.

^aBias: difference between the average value of RC across the bootstrap samples and RC in original sample.