Table 1.

NKp46 regulation of ILC function

Genetic modification	Phenotype		References
Mutation
Ly5.1C14R (C14R)	Loss of surface NKp46 expression Loss of TRAIL expression Normal NK cell and ILC1 numbers Altered NK cell maturation	Resistance to MCMV viral infection Reduced Dok‐1 augments IFN‐γ expression Complete loss of surface NKp46 expression	Jang et al82
‘Ziggy’ (C14R)		Reduced cytotoxicity by ILC1	Turchinovich et al80
Ly5.1C14R (C14R) (+ >300 additional genes)		Susceptibility to tumor	Almeida et al81
NCRB6C14R (C14R)		Unstable NKp46 surface expression	Almeida et al81
Ncr1 Noé/Noé (W32R)	Loss of surface NKp46 expression	Hyperactive NK cells Increased IFN‐γ production NKp46 retention in endoplasmic reticulum Susceptibility to tumor Increased Helios expression	Narni‐Mancinelli et al110
Ncr1 Noé/Noé (W32R)	Unstable surface NKp46 expression	Altered glycosylation of NKp46 NKp46 retention in endoplasmic reticulum	Glasner et al111, 188
Deletion
NCR gfp/gfp	Loss of intracellular and surface NKp46 expression	Susceptibility to influenza virus infection	Gazit et al108
NCR gfp/gfp		Loss of ILC1 (not observed in81, 113)	Wang et al112
NCR gfp/gfp		Reduced IFN‐γ Loss of tumor control and fibronectin 1‐driven remodeling	Glasner et al189
NCR1 iCre/iCre	Severe impairment of NKp46 expression	Normal NK cell numbers and function	Narni‐Mancinelli et al109