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. 2019 Feb 1;218(4):1218–1234. doi: 10.1083/jcb.201806195

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© 2019 Malaby et al.

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Figure 7. — KBP overexpression inhibits KIF15-driven spindle stabilization. (A) Schematic of spindle collapse assay. (B) Metaphase cells expressing mCherry (mCh) only or mCh-KBP treated with DMSO or the Eg5 inhibitor STLC. Scale bar, 10 µm. (C) Quantification of the percentage of mitotic cells with monopolar spindles, normalized to the DMSO condition. Error bars represent SD. Data were obtained from three independent experiments with the following cell numbers: mCh only DMSO (103), mCh only STLC (134), mCh-KBP DMSO (200), and mCh-KBP STLC (269). **, adjusted P = 0.0058 with 95% confidence interval by two-way ANOVA with Tukey’s multiple comparisons test.