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. 2019 Mar 7;216(4):900–915. doi: 10.1084/jem.20181290

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© 2019 Arnold et al.

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Figure 5. — Microglial dysmaturation in the absence of TGFβ signaling. (A) Volcano plots of differentially expressed genes (RNA sequencing) in microglia from Tgfbr2ΔMG versus litter mate controls at indicated time points (n = 3–4 per genotype). Green, P < 0.05 and log₂ fold change >1; red, P < 0.05; orange, log₂ fold change >1; black, P > 0.05. (B) Venn diagrams of overlaps of differentially expressed genes from E16 (yellow), P15 (blue), and P60 (pink) time points. (C) Heat map representation of differential expression Z statistics for indicated datasets. Genes are divided into immature, mature, and reactive groups based on similarity to published data (see Table S1).