Table 2.
Animals biochemistry.
| Wild | Type | ANXA1 -/- | |||||
|---|---|---|---|---|---|---|---|
| Chow | Chow + hrANXA1 | HFD+ Vehicle | HFD + hrANXA1 | Chow | HFD + Vehicle | HFD + hrANXA1 | |
| Body weight (g) | 9.790 ± 0.602* | 9.857 ± 0.674* | 16.81 ± 0.479 | 12.87 ± 0.455* | 4.550 ± 0.276$ | 13.89 ± 0.772 | 7.00 ± 0.447$ |
| Epididymal fat (mg) | 1.963 ± 0.163* | 2.100 ± 0.255* | 3.570 ± 0.291 | 2.867 ± 0.253* | 2.288 ± 0.067$ | 5.609 ± 0.246 | 4.361 ± 0.007$ |
| Inguinal fat (mg) | 1.250 ± 0.128* | 1.275 ± 0.149* | 2.320 ± 0.243 | 1.833 ± 0.212* | 0.714 ± 0.051$ | 1.842 ± 0.096 | 1.370 ± 0.094$ |
| Blood glucose (mmol/L | 8.438 ± 0.541* | 7.682 ± 0.29* | 13.86 ± 0.6621 | 9.088 ± 0.442* | 8.650 ± 0.493$ | 19.56 ± 1.224 | 8.483 ± 0.541$ |
| Serum Insulin (ng/mL) | 6.6941.282* | 7.110 ± 1.061* | 18.73 ± 2.454 | 7.860 ± 0.697* | 5.321 ± 0.238$ | 20.54 ± 1.271 | 13.47 ± 0.817$ |
| OGTT (AUC) | 84.42 ± 4.506* | 84.96 ± 3.659* | 110.7 ± 3.659 | 89.42 ± 0.999* | 87.65 ± 4.716$ | 127.6 ± 3.767 | 99.93 ± 3.560$ |
Body weight gain from baseline, epididymal fat weight, inguinal fat weight, blood glucose, serum insulin, and OGTT AUC were measured in WT C57BL/6 or ANXA1−/− mice fed a standard diet (chow) or a high-fat diet (HFD) for 10 weeks. HFD-mice were treated with either vehicle or human recombinant (hr) ANXA1 (40 μg/kg, i.p.) five times per weeks between weeks 4 and 10. Data are expressed as mean± SEM of 7–10 mice per group. Data were analyzed by a one-way ANOVA followed by a Bonferroni post-hoc test,
*
p < 0.05 vs. WT + HFD or
$
p < 0.05 vs. ANXA1 + HFD.