TABLE 1.
Clinical and Histological Data of All 12 Melanotic Schwannoma (MS) Cases
| Case # | Age/Sex | Presenting Tumor | Site | MS Histology | Mitoses/HPF | Necrosis | KI-67 | S100 & HMB45 | Follow-up |
|---|---|---|---|---|---|---|---|---|---|
| SCH1 | 48/F | Melanotic Schwannoma | Paraspinal | Epithelioid | <1/10 | Present | 5% | pos | NA |
| SCH2 | 36/F | Melanotic Schwannoma | Paraspinal | Epithelioid | None | Present | ND | ND | NA |
| SCH3 | 44/M | Melanotic Schwannoma | Chest wall | Epithelioid | 3/10 | present | ND | ND | Mets/DOD |
| SCH4 | 25/F | Melanotic Schwannoma | metacarpal | Spindle | None | None | ND | pos | NED-3 years-lost to follow-up |
| SCH5 | 44/F | Melanotic Schwannoma | Chest wall | Epithelioid | <1/10 | None | 1% | pos | NED-8 years |
| SCH6 | 53/M | Melanotic Schwannoma | Cervical Spine/recurrent | Psammomatous | None | None | 5–10% | ND | Mets/DOD |
| SCH7 | 72/M | Melanotic Schwannoma | Thoracic spine | Spindle and epithelioid | None | None | 5–10% | Pos | Alive with mets |
| SCH8 | 51/M | Melanotic Schwannoma | Sacrum | Epithelioid | None | None | 1% | pos | NED-2 years |
| SCH9 | 19/M | Atrial Myxoma followed by Melanotic Schwannoma | Paraspinal | Epithelioid | <1/10 | None | <5% | ND | NA |
| SCH10 | 33/M | Melanotic Schwannoma | Spine | Psammomatous | <1/10 | None | ND | Pos | NA |
| SCH11 | 31/M | Melanotic Schwannoma | Lung | Spindle | none | None | 2% | Pos | NED-6 months |
| SCH12 | 51/F | Melanotic Schwannoma | Orbital met | Spindle and epithelioid | 10/10 | Present | ND | ND | Alive with mets |
DOD, died of disease; NED, no evidence of disease; ND, not done; NA, not available, Met: metastasis.