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. Author manuscript; available in PMC: 2019 Apr 3.
Published in final edited form as: Exp Physiol. 2018 Sep 13;103(11):1469–1480. doi: 10.1113/EP087207

1. Mice fed rapamycin in conjunction with a high fat, high sucrose (HFHS) diet show reduced adiposity.

1.

(A) Rapamycin levels in the blood after 2–4 weeks on placebo or rapamycin-containing diets, (B) Body weight gain was measured weekly for the duration of the study, (C) Food intake measured at 5, 9 and 13 weeks, (D) Whole body fat mass and (E) lean body mass measured by body composition analysis. White bars: placebo-fed mice; black bars: rapamycin-fed mice, n=7–10 per group, *p<0.05, **p<0.01 vs placebo.