Table 3.
Self-amplifying mRNA vaccines against infectious diseases.
| Replicons | Targets | Immune response | Animal models | References |
|---|---|---|---|---|
| N/A | HA, influenza virus | Humoral and cellular | Mice | Brazzoli et al. (65) |
| N/A | M1, NP, influenza virus | Humoral and cellular | Mice | Magini et al. (63) |
| VEEV | E85, dengue virus | Humoral and cellular | Mice | Khalil et al. (80) |
| SFV | NS3, hepatitis C virus | Humoral and cellular | Mice | Lundstrom et al. (81) |
| KUNV | GP, Ebola virus | Humoral and cellular | NHP | Pyankov et al. (82) |
| RVFV | HA, influenza virus | Humoral and cellular | Mice | Oreshkova et al. (83) |
| SFV | E6, E7, papilloma virus | Humoral and cellular | Mice | Van de Wall et al. (84) |
| TBEV | Capsid protein C, TBEV | Humoral and cellular | Mice | Aberle et al. (92) |
| N/A | Gag, HIV | Humoral and cellular | NHP | Bogers et al. (85) |
| KUNV | Gag, HIV | Humoral | Mice | Harvey et al. (86) |
| JEV | Epitope SP70, EV71 | Humoral and cellular | Mice | Huang et al. (87) |
| VEEV | Pentamer, CMV | Humoral and cellular | Mice | Hofmann et al. (88) |
| SFV | prM-E, loupingill virus; HA, influenza; F, RSV | Humoral and cellular | Mice | Fleeton et al. (62) |
| N/A | F, RSV | Humoral and cellular | Mice | Geall et al. (22) |
| VEEV, SFV | HA, influenza virus; GP, Ebola virus | Humoral and cellular | Mice | Chahal et al. (64) |
| N/A | SLOdm and BP-2a Streptococci | Humoral | Mice | Maruggi et al. (89) |
| SFV | Conserved region, HIV | cellular | Mice | Moyo et al. (90) |
VEEV, Venezuelan equine encephalitis virus; HA, hemagglutinin; SFV, Semliki Forest virus; KUNV, Kunjinvirus; RVFV, Rift Valley fever virus; JEV, Japanese encephalitis virus; NHP, nonhuman primate; TBEV, tick-borne encephalitis virus; CMV, cytomegalovirus; HIV, human immunodeficiency virus; SLOdm, GAS streptolysin-O; BP-2a, GBS pilus 2a backbone protein; N/A, not known.