Table 3.
MIC of the fluoroquinolone (ciprofloxacin and levofloxacin) and amino-acid substitutions in the QRDR of the gyrA, gyrB, and parC genes of panel strains.
| MIC(μg/ml) | Amino-acid substitutions in | ||||
|---|---|---|---|---|---|
| CIP* | LEV* | gyrA | parC | gyrB | |
| ESBL | |||||
| YMC2003/5/C86 | 128, R | 32, R | S81L | E88K | A677V |
| YMC2003/1/R306 | 0.5, S | 0.75, R | S81L | – | – |
| OVER-EXPRESSED AMPCβ -LACTAMASE | |||||
| YMC2009/2/B6756 | 128, R | 6, I | S81L | S81L | – |
| YMC2012/7/R3167 | 256, R | 8, R | S81L | S81L | – |
| OXA-TYPE CARBAPENEMASES | |||||
| YMC2011/7/R812 | 0.5, S | 0.19, S | – | – | – |
| YMC2012/1/R79 | 128, R | 6, I | S81L | S81L | – |
| YMC2011/2/C582 | 128, R | 24, R | S81L | S81L | – |
| YMC2012/9/R2209 | 256, R | 16, R | S81L | S81L | – |
| METALLO-β-LACTAMASE | |||||
| YMC2013/3/R2081 | 128, R | 6, I | S81L | S81L | – |
| NARROW-SPECTRUM β-LACTAMASE | |||||
| YMC2010/8/T346 | 0.25, S | 0.19, S | – | – | – |
| NARROW-SPECTRUM OXACILLINASE | |||||
| YMC2009/2/B2968 | 0.12, S | 0.125, S | – | – | – |
*
MIC assay was performed using Disk diffusion technique and E-test for ciprofloxacin and levofloxacin, respectively.