Table 3.
Comparison of the three groups for various measures according to either mean score or proportion of patients with abnormal test performance
| Non-treatment n (%) Mean (SD)* |
Chemotherapy n (%) Mean (SD)* |
Targeted therapy n (%) Mean (SD)* |
χ2 or F | P-value | |
|---|---|---|---|---|---|
|
| |||||
| MMSE | 0 | 2 (1.8) | 2 (1.8) | 2.332 | 0.312 |
| Vocabulary | 0 | 0 | 0 | Nil | Nil |
| DSS | 6 (15) | 4 (10) | 5 (15.2) | 0.577 | 0.749 |
| Digit Span | 0 | 2 (5) | 1 (3) | 1.960 | 0.375 |
| CTT1 | |||||
| Completion time | 5 (12.5) | 2 (5) | 4 (12.12) | 1.582 | 0.453 |
| Errors | 2 (5) | 2 (5) | 1 (3.03) | 0.214 | 0.898 |
| CTT2 | |||||
| Completion time | 2 (5.4) | 1 (2.5) | 3 (9.09) | 1.523 | 0.467 |
| Number errors | 1 (2.5) | 3 (7.5) | 2 (6.06) | 1.047 | 0.593 |
| Color errors | 3 (7.5) | 3 (7.5) | 2 (6.06) | 0.074 | 0.964 |
| Overall performance | 14 (35) | 14 (35) | 10 (30) | 0.235 | 0.889 |
| HADS-A | 8 (20) | 6 (15) | 6 (18) | 0.351 | 0.839 |
| HADS-D | 8 (20) | 6 (15) | 5 (15) | 0.450 | 0.799 |
| FACT-cog | |||||
| Total score | 118.88 (9.75) | 113.90 (14.07) | 113.94 (16.25) | 1.757 | 0.177 |
| PCI | 66.80 (6.41) | 64.28 (8.84) | 64.27 (8.57) | 1.296 | 0.278 |
| CFO | 15.63 (1.00) | 15.43 (1.68) | 15.64 (1.58) | 0.262 | 0.770 |
| PCA | 21.13 (3.41) | 19.33 (3.68) | 19.91 (4.90) | 2.108 | 0.126 |
| QOL | 15.33 (1.86) | 14.88 (2.54) | 14.12 (3.90) | 1.666 | 0.194 |
Note:
*
the results of the FACT-cog are presented in Mean (SD).
Abbreviations: CFO, comments from others; CTT, Color Trails Test; DSS, Digit Symbol Substitution; FACT-cog, Functional Assessment of Cancer Therapy–Cognitive Function; HADS-A, Hospital Anxiety and Depression Scale–Anxiety; HADS-D, Hospital Anxiety and Depression Scale–Depression; PCA, perceived cognitive abilities; PCI, perceived cognitive impairments; QOL, quality of life; MMSE, Mini-Mental State Examination.