Figure 5. The T9-10 SCI contusion mouse model was not significantly associated with increased mechanical sensitivity.

Mechanical sensitivity of the right and left hind paw was measured using the Von Frey test. The percent baseline sensitivity scores from the right paw for each treatment group at each time point (4, 6, and 10 weeks post-injury) were averaged (±SEM). For the right hindpaw, which was measured for the thermal sensitivity studies, mixed-effects linear regression revealed no overall significant effect of treatment, time or their interaction (Figure 2A). The more sensitive percent baseline scores for each mouse (left vs right paw) were also averaged and statistically compared between groups and across time (Figure 2B), and mixed-effects linear regression revealed a marginally significant overall treatment effect. The less sensitive percent baseline scores for each mouse (left vs right paw) were also averaged and statistically compared between groups and across time (Figure 2C), and mixed-effects linear regression revealed a significant overall treatment effect (p < 0.04 indicated by bracket and asterisk) and a marginally significant difference between SHAM and SCI-CBD on Week 6 (p = 0.09 indicated by asterisk above data point) with multiple comparison post-test adjustments.