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. Author manuscript; available in PMC: 2019 Sep 1.
Published in final edited form as: Lung Cancer. 2018 Jun 23;123:36–43. doi: 10.1016/j.lungcan.2018.06.026

Figure 5.

Figure 5.

The combination of BMS-754807 and 2-DG suppresses the growth of LKB1-inactivated cells in vivo. Female athymic nude mice were implanted with 5 × 106 H460 cells in 100 μL PBS on the right flank. Tumors were allowed to grow to about 50mm3 (on the 6th day), then mice were allocated into 4 groups and administered vehicle control, 2-DG, BMS-754807, or the combination of 2-DG and BMS-754807. Mice were treated twice daily for 14 days. Body weight and tumor size were measured every other day, and the tumor volume was calculated with the formula [volume = 3.14 × (height × width × width)/6]. (A) Tumor volumes determined by caliper measurement. Error bars represent one S.E.M. within group. (B) Animal body weight measurements. Error bars represent one SEM. (C) Mice and xenografts in different groups. (D) Tumors were weighed upon harvest. * indicates p < 0.05.