Skip to main content
. Author manuscript; available in PMC: 2020 Jan 1.
Published in final edited form as: Pharmacol Res. 2018 Nov 1;139:1–16. doi: 10.1016/j.phrs.2018.10.027

Figure 1: Metformin treatment reverses SNI-induced mechanical and cold hypersensitivity in male mice:

Figure 1:

A-C. SNI surgery caused mechanical hypersensitivity in male mice as measured using the withdrawal frequency test. After treatment with Metformin, the response frequency was decreased for all filament weights. D. Cold hypersensitivity was induced by SNI and the effect was reduced after metformin administration. *p < 0.05; **p < 0.01; ***p < 0.001; ****p < 0.0001; ###p<0.001 versus BL; N= 9 for all groups.