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. Author manuscript; available in PMC: 2020 Jan 1.
Published in final edited form as: Pharmacol Res. 2018 Nov 1;139:1–16. doi: 10.1016/j.phrs.2018.10.027

Figure 4: Metformin does not reverse microglial activation in SNI female mice:

Figure 4:

A-D. Representative immunohistochemistry images of the dorsal horn of female lumbar spinal cord at 20X magnification. Quantification of images shown in E. SNI robustly stimulated microglial activation in female SNI mice, but metformin had no effect. A loss of IB4 staining was not observed in female SNI mice (A-B). ***p < 0.001; N= 5 per group.