Table 1.
Case | Affected limb | Skin lesions | Cranial nerve involvement | Site of biopsy; nerve /skin lesion | Duration of illness | Histological diagnosis | Acid-fast bacilli in nerve tissue/skin | PCR for lepra DNA (nerve) | PCR for 16S rRNA gene (cerebrospinal fluid) | Magnetic resonance imaging lesion (s) | On multidrug therapy before biopsy (duration) | Follow-up |
---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | All four limbs | Yes | VII | Left SRN; skin from leg | 8 years | BT | No | Positive | Negative | Facial nuclei and nerve; bilateral BP (Figure 2) | Yes | 16 months |
2 | Left hand; skin | Yes | No | Left SRN | 6 months | BT | No | Positive | Negative | C6–C7; left BP (Figure 4) | No | 8 months |
3 | Upper limbs | Yes | No | Left DCUN | 3 years | BL | Yes | Positive | Not done | C3; bilateral BP | No | 2 months |
4 | Right upper limb | Yes | No | Left SRN | 3 years | BT | No | Positive | Positive | C4–C5 hemicord lesion; bilateral BP | Yes | 4 months |
5 | Right upper limb | No | No | Left sural nerve | 1 year | BL | Yes | Positive | Not done | C4–D2; bilateral BP (Figure 7) | No | No |
6 | Left lower limb | Yes | No | Left sural; skin from leg | 2 months | BT | Yes | Positive | Not done | Left conus, lumbar plexus (Figure 7) | No | No |
7 | Left upper limb | Yes | No | Left SRN | 9 months | BT | No | Positive | Not done | Left C5–C6 (Figure 7) | No | No |
8 | All four limbs | Yes | V, VII, IX, and X | Left SRN | 8 months | BT | No | Positive | Negative | Facial nuclei and nerves, cord C2–C3, D4–D5, D7–D8, D11–D12; bilateral brachial plexus and lumbar plexus (Figure 8) | No | No |
BL = bilateral; BT = borderline tuberculoid; DCUN = dorsal cutaneous ulnar nerve; PCR = polymerase chain reaction; SRN = superficial radial nerve.