Fig 5. Forest plots illustrating non-inferiority analysis of the outcome of trypanocidal treatment by Trypanosoma spp..

Trypanosoma spp. PCR status was used as the outcome variable. The control drug (Iso = isometamidium) was compared to test drugs (Dim = diminazene (a) and Cy = melarsomine dihydrochloride (b)) for each infective species of Trypanosoma spp. at each time point (week 2 and 3). Positive treatment outcome was defined as a negative PCR result. The percentage difference in treatment outcome is presented as a point estimate (blue square) and two sided 95% confidence intervals (blue bars). Results are divided by Trypanosoma spp. (Brucei = T. brucei sp.; Congo = T. congolense; Vivax = T. vivax) and time point (week 2 and week 3). The 10% line represents M2, the accepted difference between drugs to demonstrate non-inferiority. The 60% line represents M1, the accepted difference between the control drug and the test drug to demonstrate placebo effect. a) Isometamidium (control drug) is compared to diminazene (test drug) b) Isometamidium (control drug) is compared to melarsomine dihydrochloride (test drug).