Table 5.

Effects of zearalenone (ZEA) on the relative expression of Keap1, Nrf2, GPX1, NQO1, HO1, and GCLM¹ mRNA in the jejunum of postweaning gilts

		Treatment2				P
Item1	Control	ZEA0.5	ZEA1.0	ZEA1.5	SEM	Treatment	Linear	Quadratic
Keap1	1.00a	0.58b	0.57b	0.59b	0.010	<0.001	<0.001	<0.001
Nrf2	1.00c	3.45b	4.08a	3.90a	0.080	<0.001	0.005	<0.001
GPX1	1.04c	1.45b	1.82a	1.53b	0.018	<0.001	0.002	0.002
NQO1	1.01d	1.49c	2.07b	3.16a	0.065	<0.001	<0.001	<0.001
HO1	1.00d	1.56c	2.09b	2.64a	0.061	<0.001	0.0802	<0.001
GCLM	1.00b	1.18b	2.29a	2.35a	0.057	<0.001	<0.001	<0.001

^a–dMeans within a row with different superscripts differ (P < 0.05).

¹ Nrf2 = nuclear factor erythroid 2–related factor 2; Keap1 = Kelch-like erythroid cell-derived protein with CNC homology (ECH)–associated protein 1; GPX1 = glutathione peroxidase 1; HO1 = hemeoxygenase 1; NQO1 = quinone oxidoreductase 1; GCLM = modifier subunit of glutamate-cysteine ligase.

²Control, ZEA0.5, ZEA1.0, and ZEA1.5 represent the basal diet with an additions of 0, 0.5, 1.0, and 1.5 mg/kg ZEA, respectively, with analyzed ZEA concentrations being 0, 0.52 ± 0.07, 1.04 ± 0.03, and 1.51 ± 0.13 mg/kg, respectively.