Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Aging related mutations that occur during HSC replication result in the production of a genetically heterogeneous pool of HSCs. In SCN, the persistently high level of G-CSF results in the selection of HSCs that carrying truncations mutations of CSF3R (encoding the G-CSF receptor). Additional mutations, most commonly of RUNX1, are required for transformation to MDS/AML.
