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. 2019 Apr 3;5(4):eaav7199. doi: 10.1126/sciadv.aav7199

Fig. 2. Characterization of the nonviral nanovehicles.

Fig. 2

TEM images of (A) oleate-stable UCNPs, (B) UCNPs@SiO2, and (C) UCNPs-Cas9@PEI and its EDX elemental mapping. Scale bars, 50 nm. (D) Fluorescence spectrum of the UCNPs activated by a 980-nm laser (black line) and UV-vis absorption spectrum of 4-(hydroxymethyl)-3-nitrobenzoic acid (ONA) (green line). a.u., arbitrary units. (E) The ζ potentials of Cas9 protein, Cas9/sgRNA, UCNPs@SiO2, UCNPs@SiO2-COOH, UCNPs@SiO2-ONA, UCNPs-Cas9, and UCNPs-Cas9@PEI (from left to right).