FIG 10.

Model for the role of Zfp423 in adult muscle regeneration. During adult muscle regeneration, quiescent Pax7⁺ satellite cells do not express Zfp423, but activated cells begin to express Zfp423. After extensive proliferation, cells committed to myogenic differentiation downregulate Zfp423 and fuse to form myotubes. Loss of Zfp423 results in a delay of progression from the proliferative state to the myogenic differentiation state. Thus, Zfp423 controls the proliferation of adult satellite cells to affect muscle regeneration and myogenesis.