Table 1.
Characteristics of Study Population*
| Characteristic | Women With Screen-Detected Invasive Cancer (n = 1609) |
Women With Interval Invasive Cancer (n = 351) |
Matched Control Participants (n = 4409) |
|---|---|---|---|
| Mean age (SD), y | 60.2 (11.8) | 56.6(12.2) | 59.6 (11.8) |
| Mean body mass index (SD), kg/m2† | 26.9 (5.9) | 24.1 (4.6) | 26.4 (6) |
| Median dense breast volume (IQR), ml‡ | 57.6 (41.4–80.5) | 67.0(45.9–97.8) | 51.5 (37.7–71.4) |
| Family history of breast cancer, n (%)§ | 448 (28.2) | 110(31.3) | 837 (19) |
| History of breast biopsy, n (%)∥ | 358 (22.4) | 99 (28.4) | 788 (17.9) |
| Race/ethnicity, n (%) | |||
| White | 1248 (77.6) | 263 (74.9) | 3526 (80) |
| Asian | 225 (14) | 61 (17.4) | 570 (12.9) |
| Black | 45 (2.8) | 4(1.1) | 89 (2) |
| Hispanic | 36 (2.2) | 8 (2.3) | 110(2.5) |
| Other | 55 (3.4) | 15 (4.3) | 114(2.6) |
| Clinical BI-RADS density, n (%) | |||
| Almost entirely fatty | 207 (12.9) | 19 (5.4) | 801 (18.2) |
| Scattered fibroglandular densities | 650 (40.4) | 74(21.1) | 1764(40) |
| Heterogeneously dense | 578 (35.9) | 160 (45.6) | 1469 (33.3) |
| Extremely dense | 174(10.8) | 98 (27.9) | 375 (8.5) |
| Automated BI-RADS density, n (%)‡ | |||
| Almost entirely fatty | 296 (18.4) | 23 (6.6) | 967 (21.9) |
| Scattered fibroglandular densities | 536 (33.3) | 61 (17.4) | 1395 (31.6) |
| Heterogeneously dense | 522 (32.4) | 116(33) | 1353 (30.7) |
| Extremely dense | 255 (15.8) | 151 (43) | 694(15.7) |
| BCSC 5-y risk, n (%) | |||
| Low (0%−0.99%) | 387 (24.1) | 79 (22.5) | 1373 (31.1) |
| Average (1.00%−1.66%) | 446 (27.7) | 84 (23.9) | 1210 (27.4) |
| Intermediate (1.67%−2.49%) | 399 (24.8) | 93 (26.5) | 1110(25.2) |
| High (2.50%−3.99%) | 282 (17.5) | 68 (19.4) | 528 (12) |
| Very high (≥4.00%) | 95 (5.9) | 27 (7.7) | 188 (4.3) |
BCSC = Breast Cancer Surveillance Consortium; BI-RADS = Breast Imaging Reporting and Data System; IQR = interquartile range.
*
Percentages may not sum to 100 due to rounding.
†
Data missing for 73 participants (1.1%).
‡
Measured with Volpara software (Volpara Solutions).
§
Defined as having a mother, sister, or daughter with breast cancer. Data missing for 35 participants (0.6%).
∥
Data missing for 17 participants (0.3%).