Table 2.
Risk for Screen-Detected and Interval Cancer for BI-RADS Breast Density Measured More Than 6 Months to 5 Years Before Cancer Diagnosis
| Variable | Screen-Detected Cancer |
Interval Cancer |
P Value for Interval vs. Screen- Detected Cancer |
||||
|---|---|---|---|---|---|---|---|
| Case Participants/ Control Participants, n/N |
OR (95% CI)* | C-Statistic (95% CI) |
Case Participants/ Control Participants, n/N |
OR (95% CI)* | C-Statistic (95% CI) |
||
| Clinical BI-RADS density | - | - | 0.62 (0.61–0.64) | - | - | 0.72 (0.69–0.75) | <0.001 |
| Almost entirely fatty | 207/691 | 0.62 (0.51–0.75) | - | 19/110 | 0.74(0.41–1.36) | - | |
| Scattered fibroglandular densities | 650/1481 | 1.00 (reference) | - | 74/283 | 1.00 (reference) | - | |
| Heterogeneously dense | 578/1195 | 1.26 (1.09–1.46) | - | 160/274 | 2.51 (1.74–3.61) | - | |
| Extremely dense | 174/283 | 1.83(1.44–2.32) | - | 98/92 | 5.09(3.11–8.35) | - | |
| Automated BI-RADS densityt† | - | - | 0.62 (0.60–0.63) | - | - | 0.70 (0.66–0.73) | <0.001 |
| Almost entirely fatty | 296/828 | 0.73 (0.61–0.87) | - | 23/139 | 0.73(0.42–1.29) | - | |
| Scattered fibroglandular densities | 536/1182 | 1.00 (reference) | - | 61/213 | 1.00 (reference) | - | |
| Heterogeneously dense | 522/1112 | 1.20 (1.02–1.41) | - | 116/241 | 2.22(1.44–3.43) | - | |
| Extremely dense | 255/528 | 1.43 (1.14–1.79) | - | 151/166 | 5.65 (3.33–9.60) | - | |
BI-RADS = Breast Imaging Reporting and Data System; OR = odds ratio.
*
Adjusted for age, body mass index, family history of breast cancer, history of breast biopsy, and race/ethnicity.
†
Measured with Volpara software (Volpara Solutions).