Table 3.
Risk for Screen-Detected and Interval Cancer for Recent and Distant BI-RADS Breast Density Measures Before Cancer Diagnosis
| Variable | Screen-Detected Cancer |
Interval Cancer |
P Value for Interval vs. Screen- Detected Cancer |
||||
|---|---|---|---|---|---|---|---|
| Case Participants/ Control Participants, n/N |
OR (95% CI)* | C-Statistic (95% CI) |
Case Participants/ Control Participants, n/N |
OR (95% CI)* | C-Statistic (95% CI) |
||
| Recent breast density measure† | |||||||
| Clinical BI-RADS density | - | - | 0.62 (0.59–0.65) | - | - | 0.72 (0.68–0.77) | 0.023 |
| Almost entirely fatty | 53/167 | 0.64 (0.44–0.94) | - | 7/47 | 0.61 (0.23–1.62) | - | |
| Scattered fibroglandular densities | 171/403 | 1.00 (reference) | - | 34/122 | 1.00 (reference) | - | |
| Heterogeneously dense | 164/320 | 1.36(1.02–1.81) | - | 61/104 | 2.67 (1.50–4.77) | - | |
| Extremely dense | 62/87 | 2.06(1.35–3.15) | - | 47/36 | 5.98(2.81–12.7) | - | |
| Automated BI-RADS density‡ | - | - | 0.62 (0.59–0.65) | - | - | 0.70 (0.65–0.75) | <0.001 |
| Almost entirely fatty | 64/209 | 0.56(0.38–0.81) | - | 6/63 | 0.37(0.14–1.01) | - | |
| Scattered fibroglandular densities | 144/298 | 1.00 (reference) | - | 26/77 | 1.00 (reference) | - | |
| Heterogeneously dense | 162/306 | 1.31 (0.96–1.78) | - | 51/99 | 2.44(1.20–4.97) | - | |
| Extremely dense | 80/164 | 1.38 (0.92–2.07) | - | 66/70 | 5.39(2.30–12.6) | - | |
| Distant breast density measure§ | |||||||
| Clinical BI-RADS density | - | - | 0.62 (0.60–0.64) | - | - | 0.71 (0.67–0.76) | <0.001 |
| Almost entirely fatty | 154/524 | 0.61 (0.49–0.77) | - | 12/63 | 0.84(0.38–1.84) | - | |
| Scattered fibroglandular densities | 479/1078 | 1.00 (reference) | - | 40/161 | 1.00 (reference) | - | |
| Heterogeneously dense | 414/875 | 1.22(1.02–1.45) | - | 99/170 | 2.57 (1.57–4.19) | - | |
| Extremely dense | 112/196 | 1.72 (1.29–2.31) | - | 51/56 | 4.62 (2.38–8.98) | - | |
| Automated BI-RADS density‡ | - | - | 0.62 (0.60–0.64) | - | - | 0.69 (0.65–0.74) | <0.001 |
| Almost entirely fatty | 232/619 | 0.79 (0.64–0.97) | - | 17/76 | 1.07 (0.53–2.17) | - | |
| Scattered fibroglandular densities | 392/884 | 1.00 (reference) | - | 35/136 | 1.00 (reference) | - | |
| Heterogeneously dense | 360/806 | 1.15(0.95–1.40) | - | 65/142 | 2.11 (1.20–3.69) | - | |
| Extremely dense | 175/364 | 1.44(1.10–1.89) | - | 85/96 | 6.11 (3.07–12.2) | - | |
BI-RADS = Breast Imaging Reporting and Data System; OR = odds ratio.
*
Adjusted for age, body mass index, family history of breast cancer, history of breast biopsy, and race/ethnicity.
†
Defined as >6 mo to <2 y before cancer diagnosis.
‡
Measured with Volpara software (Volpara Solutions).
§
Defined as 2–5 y before cancer diagnosis.