Appendix Table 1.
Risk for Screen-Detected and Interval Cancer for Recent and Distant BI-RADS Breast Density Measures Before Cancer Diagnosis, Among Women With Mammograms in Both Time Periods
| Variable | Screen-Detected Cancer |
Interval Cancer |
P Value for Interval vs. Screen- Detected Cancer |
||||
|---|---|---|---|---|---|---|---|
| Case Participants/ Control Participants, n/N |
OR (95% CI)* | C-Statistic (95% CI) |
Case Participants/ Control Participants, n/N |
OR (95% CI)* | C-Statistic (95% CI) |
||
| Recent breast density measure† | |||||||
| Clinical BI-RADS density | 0.63(0.60–0.66) | 0.75 (0.69–0.80) | 0.003 | ||||
| Almost entirely fatty | 54/218 | 0.44 (0.30–0.63) | 5/43 | 0.40(0.14–1.17) | |||
| Scattered fibroglandular densities | 244/509 | 1.00 (reference) | 27/86 | 1.00 (reference) | |||
| Heterogeneously dense | 190/359 | 1.26(0.98–1.64) | 60/99 | 1.83(0.97–3.47) | |||
| Extremely dense | 40/70 | 1.54(0.94–2.52) | 26/20 | 4.31 (1.64–11.3) | |||
| Automated BI-RADS density‡ | 0.63 (0.60–0.66) | 0.75 (0.69–0.80) | <0.001 | ||||
| Almost entirely fatty | 131/354 | 0.71 (0.53–0.95) | 8/58 | 0.87 (0.31–2.42) | |||
| Scattered fibroglandular densities | 191/394 | 1.00 (reference) | 23/91 | 1.00 (reference) | |||
| Heterogeneously dense | 153/289 | 1.23(0.92–1.66) | 48/60 | 5.85 (2.56–13.3) | |||
| Extremely dense | 53/119 | 1.10(0.70–1.72) | 39/39 | 9.79(3.51–27.3) | |||
| Distant breast density measure§ | |||||||
| Clinical BI-RADS density | 0.63(0.60–0.66) | 0.75 (0.69–0.80) | <0.001 | ||||
| Almost entirely fatty | 65/238 | 0.49 (0.34–0.70) | 4/44 | 0.49(0.15–1.59) | |||
| Scattered fibroglandular densities | 225/482 | 1.00 (reference) | 23/89 | 1.00 (reference) | |||
| Heterogeneously dense | 188/365 | 1.26(0.96–1.65) | 62/87 | 2.83(1.45–5.51) | |||
| Extremely dense | 50/71 | 2.09(1.30–3.34) | 29/28 | 4.40(1.75–11.1) | |||
| Automated BI-RADS density‡ | 0.63 (0.60–0.66) | 0.75 (0.69–0.80) | <0.001 | ||||
| Almost entirely fatty | 118/302 | 0.80(0.59–1.07) | 6/50 | 0.52 (0.18–1.53) | |||
| Scattered fibroglandular densities | 192/410 | 1.00 (reference) | 26/86 | 1.00 (reference) | |||
| Heterogeneously dense | 151/317 | 1.19(0.88–1.60) | 39/66 | 2.72 (1.28–5.77) | |||
| Extremely dense | 67/127 | 1.41 (0.92–2.16) | 47/46 | 6.20(2.39–16.1) | |||
BI-RADS = Breast Imaging Reporting and Data System; OR = odds ratio.
*
Adjusted for age, body mass index, family history of breast cancer, history of breast biopsy, and race/ethnicity.
†
Defined as >6 mo to <2 y before cancer diagnosis.
‡
Measured with Volpara software (Volpara Solutions).
§
Defined as 2–5 y before cancer diagnosis.