Appendix Table 2.

Mammography Sensitivity by Clinical and Automated BI-RADS Breast Density, by Timing of Density Measure Before Cancer Diagnosis, Among Women With Mammograms in Both Time Periods

Variable	Almost Entirely Fatty	Scattered Fibroglandular Densities	Heterogeneously Dense	Extremely Dense	Overall
Recent breast density measure*
Clinical BI-RADS density
Interval cancer cases	5	27	60	26	118
Screen-detected cancer cases	54	244	190	40	528
Sensitivity (95% CI), %	92 (84–99)	90(86–94)	76(71–81)	61 (49–72)	82 (79–85)
Automated BI-RADS density†
Interval cancer cases	8	23	48	39	118
Screen-detected cancer cases	131	191	153	53	528
Sensitivity (95% CI), %	94 (90–98)	89 (85–93)	76 (70–82)	58 (48–68)	82 (79–85)
Distant breast density measure‡
Clinical BI-RADS density
Interval cancer cases	4	23	62	29	118
Screen-detected cancer cases	65	225	188	50	528
Sensitivity (95% CI), %	94(89–100)	91 (87–94)	75(70–81)	63 (53–74)	82 (79–85)
Automated BI-RADS density†
Interval cancer cases	6	26	39	47	118
Screen-detected cancer cases	118	192	151	67	528
Sensitivity (95% CI), %	95 (91–99)	88 (84–92)	79 (74–85)	59 (50–68)	82 (79–85)

BI-RADS = Breast Imaging Reporting and Data System.

^*Defined as >6 mo to <2 y before cancer diagnosis.

^†Measured with Volpara software.

^‡Defined as 2–5 y before cancer diagnosis.