Appendix Table 4.
Risk for Screen-Detected and Interval Cancer for BI-RADS Breast Density Measured More Than 6 Months to 5 Years Before Cancer Diagnosis, by Study Cohort
| Variable | Screen-Detected Cancer |
Interval Cancer |
P Value for Interval vs. Screen- Detected Cancer |
||||
|---|---|---|---|---|---|---|---|
| Case Participants/ Control Participants, n/N |
OR (95% CI)* | C-Statistic (95% CI) |
Case Participants/ Control Participants, n/N |
OR (95% CI)* | C-Statistic (95% CI) |
||
| San Francisco Mammography Registry | |||||||
| Clinical BI-RADS density | 0.63(0.61–0.65) | 0.72 (0.68–0.75) | <0.001 | ||||
| Almost entirely fatty | 114/303 | 0.66(0.50–0.86) | 13/66 | 0.63(0.29–1.40) | |||
| Scattered fibroglandular densities | 407/834 | 1.00 (reference) | 54/184 | 1.00 (reference) | |||
| Heterogeneously dense | 394/745 | 1.26(1.05–1.52) | 107/194 | 2.25(1.44–3.51) | |||
| Extremely dense | 139/208 | 1.80 (1.36–2.38) | 84/69 | 5.23(2.97–9.21) | |||
| Automated BI-RADS densityt | 0.62 (0.60–0.64) | 0.71 (0.67–0.75) | <0.001 | ||||
| Almost entirely fatty | 158/371 | 0.75 (0.59–0.96) | 16/77 | 0.96(0.47–1.96) | |||
| Scattered fibroglandular densities | 314/628 | 1.00 (reference) | 39/132 | 1.00 (reference) | |||
| Heterogeneously dense | 385/704 | 1.36(1.11–1.67) | 85/172 | 2.36(1.36–4.10) | |||
| Extremely dense | 197/387 | 1.48 (1.13–1.94) | 118/132 | 5.58(2.93–10.6) | |||
| Mayo Clinic | |||||||
| Clinical BI-RADS density | 0.64(0.62–0.67) | 0.73 (0.68–0.79) | 0.001 | ||||
| Almost entirely fatty | 93/388 | 0.57 (0.42–0.76) | 6/44 | 0.78(0.26–2.31) | |||
| Scattered fibroglandular densities | 243/647 | 1.00 (reference) | 20/99 | 1.00 (reference) | |||
| Heterogeneously dense | 184/450 | 1.27 (0.99–1.64) | 53/80 | 3.70(1.83–7.48) | |||
| Extremely dense | 35/75 | 1.91 (1.17–3.10) | 14/23 | 4.10(1.34–12.6) | |||
| Automated BI-RADS density† | 0.66 (0.63–0.68) | 0.71 (0.65–0.76) | <0.001 | ||||
| Almost entirely fatty | 138/457 | 0.69 (0.53–0.90) | 7/62 | 0.41 (0.15–1.10) | |||
| Scattered fibroglandular densities | 222/554 | 1.00 (reference) | 22/81 | 1.00 (reference) | |||
| Heterogeneously dense | 137/408 | 0.97 (0.73–1.28) | 31/69 | 2.06 (0.98–4.30) | |||
| Extremely dense | 58/141 | 1.53(1.01–2.33) | 33/34 | 7.45 (2.65–20.9) | |||
BI-RADS = Breast Imaging Reporting and Data System; OR = odds ratio.
*
Adjusted for age, body mass index, family history of breast cancer, history of breast biopsy, and race/ethnicity.
†
Measured with Volpara software (Volpara Solutions).