Table 2.
Baseline and Change scores at 6 Months for Body Composition, Function, and Inflammatory Markers by Treatment Group
| Control (N=14) Mean ± SD |
P value | Protein (N=25) Mean ± SD |
P value |
P value Control vs. Protein |
|
|---|---|---|---|---|---|
| Body Composition and Physical Function | |||||
| Body Weight, kg | |||||
| Baseline, mean ± SD | 101.7 ± 16.1 | 106.6 ± 24.5 | |||
| Change at 6 months, mean ± SD | −4.8 ± 8.2 | 0.05 | −8.4 ± 7.1 | <0.001 | 0.17 |
| Fat Mass, kg | |||||
| Baseline, mean ± SD | 45.4 ± 18.9 | 51.7 ± 18.7 | |||
| Change at 6 months, mean ± SD | −3.7 ± 6.8 | 0.06 | −7.5 ± 6.4 | <0.001 | 0.09 |
| Fat Mass, % | |||||
| Baseline, mean ± SD | 47.1 ± 8.6 | 47.7 ± 8.3 | |||
| Change at 6 months, mean ± SD | −1.5 ± 3.7 | 0.17 | −3.6 ± 3.0 | <0.001 | 0.07 |
| Lean Mass, kg | |||||
| Baseline, mean ± SD | 49.4 ± 16.5 | 55.0 ± 11.4 | |||
| Change at 6 months, mean ± SD | −1.0 ± 2.8 | 0.21 | −0.9 ± 1.6 | 0.009 | 0.91 |
| BMI, kg/m2 | |||||
| Baseline, mean ± SD | 36.0 ± 5.3 | 37.5 ± 7.5 | |||
| Change at 6 months, mean ± SD | −2.3 ± 2.4 | 0.008 | −2.9 ± 2.3 | <0.001 | 0.45 |
| SPPB, Total Score | |||||
| Baseline, mean ± SD | 8.9 ± 1.1 | 8.2 ± 0.5 | |||
| Change at 6 months, mean ± SD | 0.9 ± 1.6 | 0.07 | 2.4 ± 1.9 | <0.001 | 0.028 |
| Inflammatory Markers* | |||||
| Adiponectin, ng/ml | |||||
| Baseline, mean ± SD | 21236.4 ± 8729.87 | 20007.3 ± 16990.33 | |||
| Change at 6 months, mean ± SD | 1619.1 ± 5121.5 | 0.71 | 0.12 ± 0.19 | 0.004 | 0.074 |
| Leptin, ng/ml | |||||
| Baseline, mean ± SD | 96.2 ± 108.0 | 60.6 ± 45.1 | |||
| Change at 6 months, mean ± SD | −41.0 ± 85.5 | 0.16 | −15.4 ± 24.9 | 0.001 | 0.70 |
| IL-1, pg/ml | |||||
| Baseline, mean ± SD | 0.02 ± 0.02 | 0.05 ± 0.10 | |||
| Change at 6 months, mean ± SD | −0.005 ± 0.02 | 0.26 | −0.002 ± 0.16 | 0.89 | 0.97 |
| IL-6, pg/ml | |||||
| Baseline, mean ± SD | 4.5 ± 12.3 | 1.3 ± 0.9 | |||
| Change at 6 months, mean ± SD | −2.9 ± 10.2 | 0.34 | 0.1 ± 0.6 | 0.32 | 0.14 |
| IL-8, pg/ml | |||||
| Baseline, mean ± SD | 14.1 ± 5.0 | 22.5 ± 29.3 | |||
| Change at 6 months, mean ± SD | 1.8 ± 6.2 | 0.31 | −2.3 ± 8.4 | 0.62 | 0.23 |
| TNF-α, pg/ml | |||||
| Baseline, mean ± SD | 2.4 ± 0.6 | 2.6 ± 0.6 | |||
| Change at 6 months, mean ± SD | 0.2 ± 0.5 | 0.10 | 0.1 ± 0.7 | 0.92 | 0.21 |
| CRP, ng/ml | |||||
| Baseline, mean ± SD | 6078.8 ± 6029.2 | 7556.2 ± 11157.4 | |||
| Change at 6 months, mean ± SD | −941.2 ± 7022.5 | 0.54 | −2437.8 ± 4709.3 | 0.005 | 0.34 |
| SAA, ng/ml | |||||
| Baseline, mean ± SD | 12117.4 ± 23020.4 | 15647.4 ± 33769.0 | |||
| Change at 6 months, mean ± SD | −6715.5 ± 23442.9 | 0.35 | −8150.3 ± 33956.4 | 0.22 | 0.94 |
| ICAM-1, ng/ml | |||||
| Baseline, mean ± SD | 504.4 ± 112.9 | 513.9 ± 114.8 | |||
| Change at 6 months, mean ± SD | −21.4 ± 0.1 | 0.27 | −53.0 ± 77.0 | 0.001 | 0.11 |
| VCAM-1, ng/ml | |||||
| Baseline, mean ± SD | 654.5 ± 178.3 | 649.3 ± 179.5 | |||
| Change at 6 months, mean ± SD | 6.7 ± 55.0 | 0.69 | −22.3 ± 66.4 | 0.07 | 0.14 |
| GSP, ng/ml | |||||
| Baseline, mean ± SD | 425.2 ± 113.7 | 429.6 ± 162.9 | |||
| Change at 6 months, mean ± SD | 38.5 ± 83.9 | 0.11 | −2.5 ± 93.5 | 0.46 | 0.11 |
*
P-values are based on log-transformed change scores