Table 4.
Effect of randomization to caloric restriction on measures of physical function at long-term follow-up
| EX Only (N=21) | CR+EX (N=21) | Differencea of Means (95% CI) | |
|---|---|---|---|
| 400-m walk (sec) | 346.4 (80.9) | 324.3 (51.2) | 23.2 (−19.3, 65.6) |
| SPPB summary score (0-12) | 10.8 (1.5) | 10.8 (1.6) | −0.03 (−1.02, 0.96) |
| Expanded PPB score (0-4) | 2.19 (0.48) | 2.31 (0.46) | −0.11 (−0.41, 0.19) |
| 4-m gait speed walk (m/sec) | 1.01 (0.18) | 1.06 (0.19) | −0.04 (−0.16, 0.08) |
| Lower extremity muscle strength (Nm) | 94.8 (39.2) | 83.4 (31.9) | 11.07 (−16.40, 38.53)b |
| Lower extremity muscle power (Watts) | 106.2 (44.2) | 96.3 (40.9) | 10.37 (−19.95, 40.68)b |
Mean (SD)
Differences of means for all but 400-m walk and SPPB obtained from general linear model, adjusting for study. Differences for 400-m walk and SPPB obtained from repeated measures general linear model, adjusting for study, and accounting for covariance using an unstructured covariance matrix.
Results for the differences of means obtained from general linear model, adjusting for study and gender, for lower extremity muscle strength and power are as follows: muscle strength, 9.14 (−11.61-29.88); muscle power, 6.72 (−19.83, 33.26).
Abbreviations: EX, exercise; CR, caloric restriction; sec, seconds; SPPB, Short Physical Performance Battery; PPB, Physical Performance Battery; Nm, Newton-meters; SD, standard deviation.