Table 2.

Pairwise comparisons of hypothesized contrasts between ketamine groups vs. placebo for the HAM-D-6

Model	Day	Dose group	Estimate	95% CI	Raw p	Adj. p	Cohen’s d
2-Group comparison
	Day 1	Combined	−3.25	(−5.39, −1.11)	0.00	0.01	−0.86
	Day 3	Combined	−1.87	(−4.14, 0.41)	0.11	0.11	−0.44
5-Group comparison
	Day 1	0.1 mg/kg	−3.18	(−5.93, −0.43)	0.02	0.14	−0.82
	Day 1	0.2 mg/kg	−1.13	(−3.75, 1.49)	0.39	0.79	−0.40
	Day 1	0.5 mg/kg	−4.79	(−7.35, −2.24)	0.00	0.00*	−1.21
	Day 1	1.0 mg/kg	−3.76	(−6.37, −1.15)	0.01	0.04*	−0.95
	Day 3	0.1 mg/kg	−2.04	(−5.04, 0.95)	0.18	0.72	−0.49
	Day 3	0.2 mg/kg	−0.36	(−3.18, 2.46)	0.80	0.80	−0.12
	Day 3	0.5 mg/kg	−3.21	(−5.97, −0.44)	0.02	0.14	−0.71
	Day 3	1.0 mg/kg	−1.84	(−4.65, 0.96)	0.20	0.72	−0.44

CI confidence interval; *Adj. p < 0.05