Table 1 –

List of pathogenic homologous recombination deficiency (HRD) mutations

Sample ID	Gene	Origin of mutation	Amino acid change	Nucleotide change	Mutation mechanism	Type of analysis
02	BRCA2	Germline	D3095E	c.9285C>G	Missense	Germline + somatic
03	BRCA2	Somatic	E1646Qfs*23	c.4936_4939delGAAA	Frameshift deletion	Germline + somatic
14	CHEK2	Somatic	R519X*	c.1555C>T	Nonsense	Germline + somatic
15	ATM	Somatic	E2014X*	c.6040G>T	Nonsense	Germline + somatic
18	ATR	Germline	-	c.2634-1G>A	Splicing	Germline only
19	FANCI	Germline	K808X*	c.A2422T	Nonsense	Germline only
20	FANCL	Somatic	T372Nfs*4	c.A2422T	Frameshift insertion	Germline + somatic
29	PALB2	Somatic	-	c.212-2A>G	Splicing	Germline + somatic
31	FANCG	Germline	L53Afs*4	c.156insG	Frameshift insertion	Germline + somatic
32	BRCA2	Somatic	S3147Cfs*2	c.9435_9436delGT	Frameshift deletion	Germline + somatic