Fig 6: Alterations in excitatory synaptic composition with loss of CDKL5 in cortical excitatory (CaMKIIα-positive) neurons:
A. Western blots for synaptic markers as indicated in cortical lysates from CDKL5 Fl/Y +/− CaMKIIα-Cre tissue.
B. Levels of synaptic markers as indicated relative to actin as indicated in cortical lysates from CDKL5 Fl/Y +/− CaMKIIα-Cre tissue. (Data presented ± SEM, *=P<0.05, **=P<0.005, ***=P<0.0005, Student’s t-test with Welch correction. N=4 for each genotype. Age 11-56 weeks.)
