Table 1.
Baseline demographics of the full GoDARTS cohort (n = 6731) and study cohort (n = 1364)
| Variable | Baseline population (n = 6731) | Study cohort (n = 1364) | ||
|---|---|---|---|---|
| Association with Lp-PLA2 | Association with Lp-PLA2 | |||
| β estimate (95% CI) | β estimate (95% CI) | |||
| Lp-PLA2, nmol min−1 ml−1 | 121.2 ± 34.8 | – | 113.4 ± 32.5 | – |
| Age, years | 65 ± 11 | −0.41 (−0.48, −0.34) | 67 ± 11 | −0.38 (−0.45,−0.30)*** |
| Sex (% women) | 44 | −13.87 (−15.51, −12.23)*** | 41 | −14.00 (−15.51, −12.23)*** |
| Smokers (% ever smokers) | 62 | 4.33 (2.61, 6.06)* | 63 | 4.33 (2.61, 6.05)*** |
| Statin users (% statin users) | 90 | −9.42 (−12.00, −6.85)*** | 91 | −9.63 (−12.60, −6.57)*** |
| Diabetes-controlling medication users (% users) | 75 | −4.58 (−6.40, −2.75) | 81 | −4.81 (−6.77, −2.86)** |
| Duration of diabetes, years | 7 ± 6 | −0.001 (−0.0015, −0.0007) | 9 ± 7 | −0.002 (−0.0015, −0.0007)*** |
| BMI, kg/m2 | 31 ± 6 | −0.12 (−0.25, −0.98)* | 31 ± 6 | −0.16 (−0.30, −0.02)*** |
| Baseline clinical data | ||||
| Calculated LDLc, mmol/l | 2.09 ± 0.77 | 19.70 (18.72, 20.67)*** | 2.10 ± 0.80 | 20.00 (18.54, 20.57)*** |
| HbA1c, mmol/mol | 58 ± 16 | 0.17 (0.12, 0.22)*** | 59 ± 18 | 0.16 (0.11, 0.22)*** |
| HbA1c, % | 7.5 ± 1.45 | 1.83 (1.26, 2.40)*** | 7.60 ± 1.60 | 1.83 (1.26, 2.40)*** |
| SBP, mmHg | 142 ± 19 | −0.07 (−0.11, −0.30)* | 143 ± 20 | −0.08 (−0.12, −0.03) |
| DBP, mmHg | 77 ± 12 | 0.28 (0.21, 0.35)*** | 75 ± 12 | 0.27 (0.20, 0.34)*** |
| eGFR, ml min−1 [1.73 m]−2 | 85 ± 20 | 0.05 (0.005, 0.099)* | 85 ± 20 | 0.05 (0.006, 0.1)* |
| Baseline diabetic retinopathy status (reference group DR0) | ||||
| DR0: no diabetic retinopathy, n (%) | 3207 (50.30) | −1.44 (−2.10, −0.80)*** | 548 (40.20) | −1.44 (−2.09, −0.80)*** |
| DR1: mild, n (%) | 1496 (23.50) | 464 (34.00) | ||
| DR2: moderate, n (%) | 968 (15.20) | 345 (25.30) | ||
| DR3: severe, n (%) | 16 (0.30) | 7 (0.50) | ||
| DR4: proliferative, n (%) | 684 (10.70) | – | ||
Data are mean ± SD, % or n (%) Associations were tested using univariate linear regression, with Lp-PLA2 as the outcome
***p < 0.001, **p < 0.01, *p < 0.05