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Progression of the MVA-CR19 virus production for two hybrid FB/perfusion variants, Hybrid 1 (a) and Hybrid 2 (b). Virus titers of whole cell lysates (filled circles) and permeate (crosses) are indicated for both variants. Virus titers in the supernatant (triangles) were determined only for Hybrid 2 (b). Arrows: time points of bolus feeding
