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. 2019 Feb 23;103(7):3025–3035. doi: 10.1007/s00253-019-09694-2

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© The Author(s) 2019

OpenAccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

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Fig. 4 — Progression of influenza A/PR/8/34 (H1N1) virus production for different cultivation strategies. HA titers and the corresponding total number of virions/mL are indicated for hybrid FB/perfusion (bioreactor supernatant: filled circles, permeate: crosses), perfusion (squares), and batch (triangles)